Cytochrome oxidase is a target of CO, the interaction of which results in decreased cellular respiration. CO also interacts with other proteins.The ability of the hemoglobin molecule to off-load oxygen to the periphery from the 3 other binding sites is then decreased, causing a left-shift of the hemoglobin curve and decreased peripheral tissue delivery of oxygen.Ĭarbon monoxide shifts the oxygen-dissociation curve to the left. After CO binds to hemoglobin, an allosteric change occurs in the hemoglobin molecules.
The bond between CO and hemoglobin is roughly 230-240 times the strength of the bond between oxygen and hemoglobin.
At baseline, levels up to 3 percent may be seen in nonsmokers, while smokers may have levels up to 10-15 percent. The plasma level of carboxyhemoglobin is normally quite low.Carbon monoxide rapidly diffuses across the capillary membrane and binds to hemoglobin to form Carboxyhemoglobin.Other potential sources include: fuel powered ovens, gasoline-powered electrical generators, motor vehicles especially in poorly ventilated spaces, motorboat exhaust, household fires, and underground electrical cable fires.
#CARBON MONOXIDE SYMPTOMS TONGUE PORTABLE#
Additionally, according to the Nelson Textbook of Pediatrics, CO exposure in recent years has been seen especially from sources such as malfunctioning portable generators in hurricane-related visits to healthcare facilities.It most commonly occurs in cold climates during the winter. Accidental exposure shows seasonal and regional variation.CO poisoning is responsible for up to 40,000 emergency department visits and 5000 to 6000 deaths per year.It is the most common gas exposure among the pediatric population. Carbon monoxide is an odorless, colorless, tasteless gas produced from incomplete combustion of organic materials.
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